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The region of the heart that initiates the heartbeat is the...

  1. Atrioventricular Node

  2. Purkinje Fibers

  3. Sinoatrial Node

  4. Bundle of HIS

The correct answer is: Sinoatrial Node

The region of the heart that initiates the heartbeat is known as the sinoatrial node. This is because the sinoatrial node, also known as the pacemaker of the heart, is responsible for setting the pace and initiating the electrical impulses that stimulate the heart to contract. The other options listed, the atrioventricular node, Purkinje fibers, and Bundle of HIS, are all components of the heart's electrical conduction system, but they do not initiate the heartbeat like the sinoatrial node does.